NCT02891109

Regulatory B Cells and Chronic Immune Thrombocytopenia

The Role of Regulatory B Cells in the Chronic Immune Thrombocytopenia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 36 (actual)
• Sponsor: University Hospital, Brest · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown.

Detailed description

The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown. In our cohort of chronic immune thrombopenia and controls, we realized a flow cytometry analyze of B and T cells and a co-culture to determine regulatory B cells functionality.

Conditions

• Purpura, Thrombocytopenic, Idiopathic
• Regulatory B Cells

Interventions

Type	Name	Description
BIOLOGICAL	Biological tests	From the blood: B and T cells extraction then co-culture B and T cells and characterization of lymphocytes by flow cytometry

Timeline

• Start date: 2015-01-01
• Primary completion: 2015-09-01
• Completion: 2015-09-01
• First posted: 2016-09-07
• Last updated: 2016-09-07

Locations

1 site across 1 country: France