Trials / Completed
CompletedNCT02890849
Clinical Research for the Consistency Analysis of PD-L1 in Cancer Tissue and Plasma Exosome
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 60 (actual)
- Sponsor
- Xinqiao Hospital of Chongqing · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
The detection of tissue PD-L1 immunohistochemistry in Non-small cell lung cancer (NSCLC) has an important role in guiding for the treatment of immune detection point. At the same time,tissue detection is time-consuming and laborious, liquid biopsy can reflect the information of tumor tissue,PD-L1 mRNA in plasma exosomes (pExo) is expected to be simple, rapid, non-invasive means of detection. The project is planned to explore the consistency analysis of PD-L1 expression level detected in cancer tissues and pExo.We have designed to detected the expression levels of PD-L1 mRNA and protein in cancer tissue and detected the expression levels of PD-L1 mRNA in pExo.By using variance analysis of repeated measures design information. Thus exploring the consistency analysis of PD-L1 expression level detected in tissues and pExo,guiding clinical practice of radiotherapy combining with immunotherapy.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Liquid biopsy |
Timeline
- Start date
- 2016-10-01
- Primary completion
- 2019-06-01
- Completion
- 2019-08-01
- First posted
- 2016-09-07
- Last updated
- 2024-02-23
Source: ClinicalTrials.gov record NCT02890849. Inclusion in this directory is not an endorsement.