NCT02889224

In Vivo Study of Interactions Between the Endocannabinoid System and the Corticotropic Axis in Man

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University Hospital, Bordeaux · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Working hypothesis: the interactions between the endogenous endocannabinoïds (ECS) - and cortisol, the end product of the Hypothalamo-Pituitary-Adrenal (HPA) axis may play a role in the pathophysiology of Cushing's syndrome. The investigators speculate that: * acute or chronic variations in plasma cortisol may induce changes in the activity of the ECS * that there is a circadian rhythm of the ECS driven by the rythm of plasma cortisol

Detailed description

The study aim to identify the relationship between the ECS and the HPA axis in humans with a main objective to assess if Cushing's syndrome induces changes in the ECS activity. For this purpose: 1. the investigors will compare plasma levels of ECS between obese controls and patients with Cushing's syndrome 2. the investigors will compare plasma levels of ECS in patients with Cushing's syndrome before and immediately after curative surgery 3. the investigors will compare plasma levels of ECS in patients with hypoadrenalism before and after the intake of substitutive doses of hydrocortisone 4. the investigors will evaluate the plasma levels of ECS during a short synacthen test in healthy subjects.

Conditions

• Cushing's Syndrome

Interventions

Type	Name	Description
OTHER	Obese
PROCEDURE	Hypercortisolism
OTHER	Hydrocortisone
OTHER	Control

Timeline

• Start date: 2012-02-01
• Primary completion: 2013-09-01
• Completion: 2013-09-01
• First posted: 2016-09-05
• Last updated: 2018-10-16

Locations

1 site across 1 country: France