NCT02881502

Clinical Study of Relationship Between Granulocyte Activation, HDAC2 and Severe Asthma

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Program： Clinical Study of Relationship Between Granulocyte Activation, HDAC2 and Severe Asthma Aim：The early prediction of severe asthma, early intervention on the disease, reduce the family and the national finance. design:This study is a single center randomized controlled trial designed by the Department of respiratory medicine, Xijing Hospital, as the main research unit.Compare the case group(severe asthma group and mild-and-moderate asthma group) and control group(healthy control group) by detecting the activity of MPO、NE、MMP-9 and ECP in the peripheral blood and the activity of HDAC2 in PBMCs of patients. case:60 Case selection: Inclusion criteria: age 18-75 years old; diagnosis of asthma was clear; informed consent was signed. Exclusion criteria: poor compliance; cognitive ability is low; psychiatric disorders need to be combined with psychotropic medication.

Detailed description

Application of SPSS 19 statistical software. Measurement data were expressed as mean ± standard deviation. First the data is normality tested and homogeneity of variance tested, according to the measurement data of normal distribution by SNK single factor analysis of variance; does not conform to the normal distribution of measurement data, using the Kruskal Wallis non parametric test. P \< 0.05 for the difference was statistically significant.

Conditions

• Asthma

Interventions

Type	Name	Description
OTHER	severe asthma group	No intervention

Timeline

• Start date: 2016-06-01
• Primary completion: 2017-07-01
• Completion: 2017-07-01
• First posted: 2016-08-29
• Last updated: 2016-08-29

Locations

1 site across 1 country: China