NCT02881047

Ablative Fractional Laser for Sclerotic GVHD-Associated Joint Contractures

Ablative Fractional Laser Resurfacing for the Treatment of Scars and Contractures Caused by Sclerotic Skin Changes Chronic Graft Versus Host Disease

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Abramson Cancer Center at Penn Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Graft versus host disease (GVHD) is a common complication of allogeneic stem cell transplant.Chronic GVHD is characterized by skin thickening and tightening. Advanced sclerosis can lead to reduced range of motion and incapacitating joint contractures. Once present, there are few therapeutic options. We will treat sclerosis and limb contractures with an ablative fractional laser, a device FDA-approved for scar treatment. This approach has successfully treated contracturesdue to burn scars.

Conditions

• Subjects With Severe, Refractory Sclerotic Skin Changes

Interventions

Type	Name	Description
DEVICE	CO2 Laser	Perform ablative fractional resurfacing using a 10,600nm carbon dioxide (CO2) laser targeted to thickened, sclerotic plaques causing range of motion limitation and contracture across joints.
RADIATION	Ultrasound	Patients will undergo ultrasound of the planned treatment site to measure skin thickness and blood flow via Doppler ultrasound.
DIAGNOSTIC_TEST	Skin Biopsy	standard 4mm punch biopsy of the skin at the planned treatment site for histologic assessment of skin thickness and sclerosis.

Timeline

• Start date: 2013-11-11
• Primary completion: 2016-08-01
• Completion: 2016-08-19
• First posted: 2016-08-26
• Last updated: 2020-04-16
• Results posted: 2020-04-16

Locations

1 site across 1 country: United States