NCT02880384

Pathogen Detection and Community Acquired Pneumonia

Projected Influence of Enhanced Pathogen Detection on the Clinical Management of Community-Acquired Pneumonia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 570 (actual)
• Sponsor: Providence Health & Services · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Study to compare the number of community-acquired pneumonia (CAP) pathogens detected using current diagnostic tests to the number detected using the BioFire Diagnostics investigational polymerase chain reaction (PCR) platform.

Detailed description

Patients diagnosed in the emergency department with CAP that requires hospitalization provide a sputum sample for culture and sensitivity testing, urine for detection of S. pneumonia and L. pneumophila, an anterior nasal swab for S. aureus PCR, a nasopharyngeal swab for S. pneumonia PCR and the FilmArray LRTI v.2.0 IUO Panel, and blood for procalcitonin testing and, in cases in which the patient is suffering rigors and hypotension, cultures. As part of this study, sputum or sputum equivalent will be acquired for testing using the FilmArray LRTI v.2.0 IUO Panel.

Conditions

• Community Acquired Pneumonia

Interventions

Type	Name	Description
OTHER	FilmArray LRTI v.2.0 IUO Panel	Patients will provide sputum or sputum equivalent to be probed with FilmArray LRTI v.2.0 IUO Panelpanel.

Timeline

• Start date: 2017-01-01
• Primary completion: 2018-04-01
• Completion: 2020-12-20
• First posted: 2016-08-26
• Last updated: 2022-05-25

Locations

1 site across 1 country: United States