NCT02877784

Screening in Oculopharyngeal Muscular Dystrophy

Determination of Accurate Screening Tools for Dysphagia in Oculopharyngeal Muscular Dystrophy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 8 (actual)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Oculopharyngeal muscular dystrophy (OPMD) is a rare myopathic disease that results in progressive degeneration of the oral and pharyngeal muscular, resulting in severe dysphagia and dysarthria. OPMD is considered a rare disease; therefore, limited research is available on the natural progression of the disease or the utility of biomarkers to identify swallowing impairment. The aim of this study is: 1. To identify accurate, reliable and non-invasive clinical markers of swallowing impairment 2. To determine the discriminate ability of these markers to identify impairments in swallow safety and swallowing efficiency.

Detailed description

Participants will be recruited from the Neurology clinic at the University of Florida. The single evaluation will occur in the PIs research laboratory at the University of Florida, Gainesville, Florida.

Conditions

• Oculopharyngeal Muscular Dystrophy

Interventions

Type	Name	Description
PROCEDURE	Videofluoroscopic swallowing study	Videofluoroscopic swallowing study will be performed to measure the oropharyngeal swallowing.
OTHER	Functional Oral Intake Scale	The Functional Oral Intake Scale (FOIS) will be used for participants to report their food intake habits.
OTHER	Eating Assessment Tool-10	The Eating Assessment Tool-10 will be used for participant reporting of swallowing system severity.

Timeline

• Start date: 2016-10-01
• Primary completion: 2017-08-01
• Completion: 2017-08-01
• First posted: 2016-08-24
• Last updated: 2020-03-27

Locations

1 site across 1 country: United States