Trials / Completed
CompletedNCT02876198
Study of the Modification of the Retinal Nerve Fiber Layer in Patients Treated With Intravitreous Injection of Anti-VEGF
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 74 (actual)
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild · Network
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The intra-vitreous injection (IVT) of anti-VEGF (vascular endothelial growth factor) is currently the standard treatment for retinal neovascularization. The VEGF stimulates endothelial cells' proliferation and migration. It also increases microvascular permeability. If the VEGFs have proven their efficiency in the decrease of choroidal neovascular proliferation, their impact of the head of the optic nerve's microvasculature is yet unknown. Knowing that this microvasculature provides the retinal nerve fibers with oxygen, located in the area of the head of the optic nerve, a vasoconstriction induced by the anti-VEGF may have an incidence on the loss of retinal nerve fibers.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Gonioscopy | Study of the trabecular structure by gonioscopy |
Timeline
- Start date
- 2016-07-01
- Primary completion
- 2021-01-30
- Completion
- 2021-04-15
- First posted
- 2016-08-23
- Last updated
- 2021-08-03
Locations
3 sites across 1 country: France
Source: ClinicalTrials.gov record NCT02876198. Inclusion in this directory is not an endorsement.