NCT02875886

DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Erasmus Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

In this clinical study the anti-hypertensive response to dietary salt restriction is compared with the anti-hypertensive response to the diuretics hydrochlorothiazide/amiloride in adult patients with chronic kidney disease.

Detailed description

Patients with chronic kidney disease (CKD) are exquisitely salt-sensitive. Salt-sensitivity in CKD is linked to hypertension and cardiovascular outcomes. Dietary salt restriction is an accepted intervention for salt-sensitivity in CKD. Another strategy, however, could be to block sodium uptake by the kidney pharmacologically by diuretics. Especially diuretics acting on the distal tubule may be effective, because this appears to be the site of increased sodium reabsorption in CKD. It is currently unknown how these two strategies, diet or diuretics, relate. The investigators hypothesize that diuretics are non-inferior to diet.

Conditions

• Chronic Kidney Disease

Interventions

Type	Name	Description
DRUG	Amiloride	Combined with hydrochlorothiazide
DRUG	Hydrochlorothiazide	Combined with amiloride
OTHER	Low-sodium diet

Timeline

• Start date: 2016-09-01
• Primary completion: 2018-04-01
• Completion: 2018-04-01
• First posted: 2016-08-23
• Last updated: 2018-04-20

Locations

1 site across 1 country: Netherlands