NCT02875639

A Clinical Research of Qi Deficiency and Blood Stasis Syndrome (Different Disease With Syndrome)

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: Zhu Mingjun · Academic / Other
• Sex: All
• Age: 40 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The main purpose of this research is to reveal the curative effect mechanism of Yiqihuoxue prescription which treat the disease of qi deficiency and blood stasis. And at the same time this study also try to confirm yiqi huoxue fang qi deficiency blood stasis treatment of coronary heart disease (CHD) heart failure the curative effect and security.

Detailed description

Modern research has shown that the main mechanism of the qi deficiency and blood stasis of coronary disease combined with cardiac failure is the disorder Nerve-endocrine-immune network mechanism, disorder of energy metabolism, blood coagulation/anticoagulation imbalances, vascular endothelial injury and the expression of inflammatory factors and cytokines disorder, etc. Some studies have identified that the Chinese traditional medicine of supplementing qi and activating blood circulation drugs could adjust the nerve - endocrine - immune network, improve endothelial function, improve ventricular remodeling, ameliorate heart function, alleviate the clinical symptoms, enhance the quality of life, and so on. This study by comparing the curative effect of Yi-Qi Formula, Huoxue prescription and two prescription of yiqi huoxue (buyang huanwu decoction and Qishen Yiqi Drop Pill) on improving energy metabolism, ameliorating heart function, adjusting the blood coagulation and the expression of cell adhesion factor, improving endothelial function, to reveal the curative effect mechanism of Yiqihuoxue prescription which treat the disease of qi deficiency and blood stasis, and confirm the TCM theory that "Qi and blood are correlated.

Conditions

• Ischemic Heart Failure

Interventions

Type	Name	Description
DRUG	Yiqi prescription
DRUG	Huoxue prescription
DRUG	Buyang huanwu decoction
DRUG	QISHEN YIQI DRIPPING PILLS
DRUG	Placebo 1	Placebo 1：a drug which imitated QISHEN YIQI DRIPPING PILLS,but do not have active ingredient,just have the excipient.
DRUG	Placebo 2	Placebo 2：a drug which imitated Buyang huanwu decoction,but do not have active ingredient,just have the excipient.

Timeline

• Start date: 2016-06-01
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2016-08-23
• Last updated: 2016-08-23

Locations

1 site across 1 country: China