NCT02874638

Effect of Non-essential Amino Acids on Protein Requirements for Endurance Athletes

Effect of Non-essential Amino Acids on Protein Requirements for Endurance Athletes Using Indicator Amino Acid Oxidation Method.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 7 (actual)
• Sponsor: University of Toronto · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA). The biological value of protein depends on its amino acid composition. Essential amino acids are believed to have main role on whole body protein metabolism. However, it remains to be determined what role non-essential amino acids (NEAA) may have in regulating protein metabolism and contributing to the increased protein requirements after endurance exercise. The indicator amino acid oxidation (IAAO) method has clarified the individual amino acid requirement in children, normal healthy adult and clinical populations. However, the IAAO method has never been utilized for assessing the effect of NEAA on protein requirements after endurance exercise. The objective of the current study is to investigate the importance of NEAA for endurance-trained male subjects.

Conditions

• Increased Metabolic Requirement
• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	BASE egg protein	0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein
DIETARY_SUPPLEMENT	BCAA-enriched egg protein	BCAA-enriched egg protein provided as crystalline amino acid.
DIETARY_SUPPLEMENT	small amount of essential amino acids	essential amino acids modeled after egg protein, provided as crystalline amino acid, which is equivalent to the amount of essential amino acid in BASE egg protein
DIETARY_SUPPLEMENT	large amount of essential amino acids	essential amino acids modeled after egg protein, provided as crystalline amino acid, which is equivalent to the amount of amino acid in BCAA-enriched egg protein

Timeline

• Start date: 2016-09-01
• Primary completion: 2017-08-01
• Completion: 2017-12-31
• First posted: 2016-08-22
• Last updated: 2019-04-01