NCT02872818

Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia

The Effect of Metformin and Medroxyprogesterone Acetate on Apoptotic Signaling Pathways in Wistar-Albino Rats With Induced Endometrial Hyperplasia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Kayseri Education and Research Hospital · Other Government
• Sex: Female
• Age: 8 Weeks – 10 Weeks
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to determine apoptotic signaling pathways such as Survivin, Bcl-2, Bax, c-Myc and caspase-9 expression levels in rats model with iatrogenic endometrial hyperplasia after metformin and medroxyprogesterone acetate administration.

Conditions

• Apoptotic Signal Pathways in Endometrial Hyperplasia

Interventions

Type	Name	Description
DRUG	17β estradiol hemihydrate	4mg/kg/day for 20 days
DRUG	Metformin	50 mg/kg/day last 10 days
DRUG	medroxyprogesterone acetate	1mg/kg/day last 10 days

Timeline

• Start date: 2014-10-01
• Primary completion: 2015-03-01
• Completion: 2015-03-01
• First posted: 2016-08-19
• Last updated: 2016-08-23

Locations

1 site across 1 country: Turkey (Türkiye)