NCT02869464

UVA Brain and Aortic Aneurysm Study

The University of Virginia Brain and Aortic Aneurysm Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 360 (estimated)
• Sponsor: University of Virginia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the percentage of patients who present with abdominal aortic aneurysms (AAA) will also have intracranial aneurysms (IA) and conversely; to examine the percentage of patients who present with intracranial aneurysms will also have abdominal aortic aneurysms.

Detailed description

The investigators have previously generated estimates for cost effectiveness of each arm of this reciprocal screening protocol based on literature dervied estimates of coprevalence and other key factors in a decision tree model to compare costs and outcomes. They measured expected outcomes using quality-adjusted life years (QALY) and the incremental cost-effectiveness ratios (ICER). The current study will involve establishment of the true co-prevalence and recalculation of the ICERs and QALYs. Based on their literature derived models we previously found an ICER of $34.01/QALY for AAA screening in IA patients and an ICER of $6,401.91/QALY for IA screening in AAA patients. Both of these are well below the societal accepted threshold of $60,000/QALY. However, both models were sensitive to co-prevalence. In the current study the investigators will therefore determine the actual cost-effectiveness of performing additional radiographic procedures and genetic counseling. The investigators will also bank DNA and RNA for future research.

Conditions

• Intracranial Aneurysm
• Abdominal Aortic Aneurysm

Interventions

Type	Name	Description
OTHER	Imaging-Ultrasound	Abdominal Ultrasound
OTHER	Imaging-MRA	Non-contrast Enhanced Magnetic Resonance Angiogram
GENETIC	DNA, RNA testing	To test for the co-prevalence of shared genetic markers in afflicted populations.

Timeline

• Start date: 2014-04-01
• Primary completion: 2017-04-01
• First posted: 2016-08-17
• Last updated: 2016-08-17

Locations

1 site across 1 country: United States