NCT02868619

Binge Eating Disorder and Obesity : Functional MRI Study

Binge Eating Disorder and Obesity : Reward System Abnormalities in Response to Food Stimuli and Research Operability by Deep Brain Stimulation Criteria: Functional MRI Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: University Hospital, Montpellier · Academic / Other
• Sex: All
• Age: 12 Years – 16 Years
• Healthy volunteers: Accepted

Summary

Obesity, defined as BMI\> 30kg / m2, is a major public health problem, with devastating medical and psychological consequences. 30% of obese suffer from BED type of eating disorders. The optimal treatment of obesity remains bariatric surgery, failed in 20% of cases. Many arguments are in favor of the involvement of the reward circuitry, with the central role of NAc in the pathophysiology of BED and obesity. The recent application and effectiveness of DBS (Deep Brain Stimulation) in refractory psychiatric disorders suggest that DBS may be of interest in treating obesity and BED with potential target for the NAc. This project propose to study fMRI activation of the reward system in response to food stimuli to better direct the DBS targets. This is a pilot study to define indication criteria based on fMRI to obese BED patients are potential candidates for treatment with DBS.

Detailed description

The aim of this functional neuroimaging study is to analyze brain responses to visual food cues in obese (body mass index \> 97th percentile) adolescents with BED (according to the criteria Marcus and Kalarchian) compared with healthy control adolescents in two situations : hunger et satiety. Fifteen obese adolescents (12/16 years) with BED and fifteen healthy control adolescents will be enrolled in the study protocol. Participants will be instructed not to eat food for at least 6 hours prior to the first imaging session. After the initial set of functional and anatomic scans, participants will be fed a standard calorie meal. Approximately 1 hour later, the experiment will be repeated while participants are in a satiated condition. The cortical fMRI activation will be measured during the following four experimental visual conditions : high calory food, low calory food, disgust and neutral presented in block design. First-level and second-level differences in neural activation assessed during functional MRI in the different conditions will then be analyzed.

Conditions

• Binge Eating Disorder
• Obesity

Interventions

Type	Name	Description
OTHER	Functional MRI	functional MRI assessed on all the volunteers in condition of hunger and in Condition of satiety
OTHER	ADO-BEDS scale	Evaluate the severity of BED according to Marcus and Kalarchian temporary diagnosis criteria
OTHER	R-CMAS scale	Evaluate the anxiety

Timeline

• Start date: 2014-12-05
• Primary completion: 2021-03-10
• Completion: 2021-03-10
• First posted: 2016-08-16
• Last updated: 2021-05-18

Locations

1 site across 1 country: France