NCT02867163

Tranexamic Acid and Blood Clots in Knee Surgery

Does the Intraoperative Administration of Tranexamic Acid (TXA) Increase the Incidence of Deep Venous Thrombosis in Total Knee Arthroplasty?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 25 (actual)
• Sponsor: University of New Mexico · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is an observational trial to estimate the incidence of deep vein thrombosis (DVT) in total knee replacement patients who received an intraoperative dose of tranexamic acid.

Detailed description

This study is anticipated to consist of 30 participants over 18 years of age scheduled for total knee arthroplasty at Sandoval Regional Medical Center with administered intraoperative tranexamic acid, who do not meet the exclusion criteria. The patients will be examined on postoperative day 1. Lower-extremity ultrasound will be used to screen for deep vein thrombosis (DVT). Incidence data for DVT will then be compared with the historical incidence rate at our institution for total knee arthroplasty without the use of tranexamic acid, which is approximately 12%. Patients found on screening to have deep vein thrombosis will be referred for appropriate care.

Conditions

• Venous Thrombosis

Interventions

Type	Name	Description
DRUG	Tranexamic Acid	Intravenous or local administration of TXA, in any dosage

Timeline

• Start date: 2017-05-16
• Primary completion: 2017-11-08
• Completion: 2017-11-08
• First posted: 2016-08-15
• Last updated: 2019-05-20
• Results posted: 2019-05-20

Locations

1 site across 1 country: United States