Trials / Completed
CompletedNCT02862860
Search for a Link Between the Different Variables for Glycaemia and Oxidative Stress or Impaired HDL Function
Influence of Glycaemic Variability on Oxidative Stress and High-density Lipoprotein (HDL) Function in Type-1 Diabetes
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 60 (actual)
- Sponsor
- Centre Hospitalier Universitaire Dijon · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
As glycaemic variability on the one hand and hypoglycaemia on the other are associated with oxidative stress and inflammation, they are likely, in type-1 diabetic patients, to affect the oxidation of lipoproteins and HDL function, by altering their anti-atherogenic properties. The aim of this study is thus to determine, in patients with Type 1 Diabetic (T1D) who will wear a glycaemic Holter for 1 week, the glycaemia parameters (mean glycaemia, duration of hypoglycaemia, duration of hyperglycaemia, mean amplitude of glycaemic excursions) associated with proatherogenic alterations in lipoproteins, in particular: * LDL oxidation * HDL oxidation and alterations of HDL function (anti-inflammatory capacity, antioxidant capacity)
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | blood sample | |
| BIOLOGICAL | urine sample | |
| DEVICE | installation of Holter |
Timeline
- Start date
- 2012-05-29
- Primary completion
- 2018-04-17
- Completion
- 2018-04-17
- First posted
- 2016-08-11
- Last updated
- 2024-02-21
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT02862860. Inclusion in this directory is not an endorsement.