NCT02858479

Structural and Functional Brain Reorganization in Neuropathic Pain. Influences of the Loss of Sensitivity and the Atrophy Cortical on Activations Due to Stimulation Allodynic

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 41 (actual)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation). This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain. It induces a loss of sensitivity and reorganization of brain activity. Previous studies in functional neuroimaging have focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally. The objective of this study is to understand the brain dysfunction that induces allodynic pain considering the deafferentation of each patient and possible cortical losses.

Conditions

• Neuropathic Pain

Interventions

Type	Name	Description
OTHER	stimulation on painful area (area allodynic)	these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable. stimulations for 6 seconds
OTHER	same stimulation on non-painful area	these stimulations will be performed either with a brush, with a cold block or with forced air (cold air or air to ambient temp) : calibrated to induce pain bearable. stimulations for 6 seconds
RADIATION	MRI scan	2 sessions for 10 minutes : * 11 controls stimulations for 6 s each spaced 20 s without stimulation. * 11 allodynic stimulations for 6 s each spaced 20 s without stimulation.

Timeline

• Start date: 2016-03-25
• Primary completion: 2019-02-11
• Completion: 2019-02-11
• First posted: 2016-08-08
• Last updated: 2020-09-28

Locations

1 site across 1 country: France