NCT02856880

A Study to Investigate the Antimicrobial Activity of 2 Test Toothpastes

A Study to Investigate the Antimicrobial Activity of Two Test Toothpastes in a Plaque Glycolysis and Regrowth Model

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: GlaxoSmithKline · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of this exploratory study is to assess the ability of two test toothpastes containing 0.6% w/w zinc chloride stabilised with sodium citrate in a sodium lauryl sulfate (SLS)-containing base to reduce glycolytic metabolism and viability of de novo plaque bacteria using the plaque glycolysis regrowth model (PGRM).

Conditions

• Dental Plaque

Interventions

Type	Name	Description
OTHER	Test zinc-IPMP toothpaste	Test toothpaste containing 0.6% w/w zinc chloride and 0.1% w/w IPMP and 1426ppm fluoride as sodium fluoride.
OTHER	Test zinc non- IPMP toothpaste	Test toothpaste containing 0.6% w/w zinc chloride, 0% w/w IPMP and 1426ppm fluoride as sodium fluoride.
OTHER	Positive control	Positive control toothpaste containing 0.454% w/w stannous fluoride (Fluoride Toothpaste (1100ppm Fluoride as stannous fluoride)).
OTHER	SLS negative control	Negative control toothpaste containing 2.0% SLS, 0.65% Tegobetain and 1150 ppm fluoride as sodium fluoride
OTHER	non-SLS negative control	Negative control toothpaste containing 1426 ppm fluoride as sodium fluoride

Timeline

• Start date: 2015-11-09
• Primary completion: 2015-12-01
• Completion: 2015-12-11
• First posted: 2016-08-05
• Last updated: 2017-08-30
• Results posted: 2017-03-03

Locations

1 site across 1 country: United Kingdom