NCT02856204

Shotgun Sequencing in Diagnosing Febrile Neutropenia in Patients With Acute Myeloid Leukemia

Shotgun Sequencing for Etiologic Diagnosis of Febrile Neutropenia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 56 (actual)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This research trial studies the shotgun sequencing of blood samples in diagnosing febrile neutropenia in patients with acute myeloid leukemia. Studying samples of blood from patients with acute myeloid leukemia in the laboratory may help identify pathogens and accurately diagnose infections such as febrile neutropenia.

Detailed description

PRIMARY OBJECTIVES: I. To test the hypothesis that shotgun metagenomics is not inferior to standard of care diagnostics in the detection of pathogens in patients with febrile neutropenia. SECONDARY OBJECTIVES: I. To establish a microbiological diagnosis with known or unknown pathogens in patients in whom standard care failed to yield a pathogenic diagnosis. OUTLINE: Patients undergo collection of blood samples before and during the episode of febrile neutropenia for up to 6 weeks.

Conditions

• Acute Myeloid Leukemia
• Febrile Neutropenia

Interventions

Type	Name	Description
OTHER	Cytology Specimen Collection Procedure	Undergo collection of blood
OTHER	Laboratory Biomarker Analysis	Correlative studies

Timeline

• Start date: 2016-08-01
• Primary completion: 2017-12-01
• Completion: 2019-04-01
• First posted: 2016-08-04
• Last updated: 2019-05-16

Locations

1 site across 1 country: United States