NCT02854943

Investigation of Ferritin in Critically Ill Patients With Hemophagocytic Lymphohistiocytosis

The Prognostic and Diagnostic Value of Ferritin in Critically Ill Patients With Special Focus on Underlying Hemophagocytic Lymphohistiocytosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 2,623 (actual)
• Sponsor: Gunnar Lachmann · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Retrospective analysis of ferritin, outcome and HLH-criteria in critically ill patients.

Detailed description

The study is a retrospective register study of critically ill patients from Charité - Universitätsmedizin Berlin during 2000 and 2016 that had at least one measurement of plasma ferritin. Outcome, underlying diagnoses and HLH-2004 criteria (Henter JI et al. 2007) will be analyzed and the HScore of these patients will be calculated (Fardet L et al. 2014). All recorded data of the specific admission term in ICU will be used for the analysis. No follow-up of the patients after discharge will be performed in this study. The study does not involve any randomization or any drug testing. Update 2019: We expanded our database for the years until 2018 and also for the surgical and medical ICUs of the Charité - Universitätsmedizin Berlin (from 256 to 2623 patients). Update 2022: A systematic literature search will be performed to find suitable validation cohorts for multicenter validation of optimized HLH diagnostic criteria, which are calculated based on our data (new secondary endpoint).

Conditions

• Hemophagocytic Lymphohistiocytosis (HLH)
• Macrophage Activation Syndrome (MAS)
• Hemophagocytic Syndromes

Timeline

• Start date: 2000-01-01
• Primary completion: 2018-08-01
• Completion: 2018-08-01
• First posted: 2016-08-04
• Last updated: 2022-12-07