NCT02854475

Confocal Raman Spectroscopy: in Vivo Measurement of Physiological Skin Parameters

Confocal Raman Spectroscopy: in Vivo Measurement of Physiological Skin Parameters - A Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to I. determine several skin parameters, for example natural moisturizing factor (NMF) and cholesterol, with Raman spectroscopy in vivo and II. compare the results with the corresponding cholesterol levels measured in venous blood.

Detailed description

In vivo Raman experiments will be carried out weekly on voluntary participants using a RiverDiagnostics gen2-SCA Skin Composition Analyzer (RiverDiagnostics, Rotterdam, Netherlands). All experiments will be carried out on the volar forearm. Semi-quantitative concentration profiles for several skin parameters will be determined, for example natural moisturizing factor (NMF) and cholesterol. Additionally the total cholesterol level will be detected by venous blood sample analysis. The blood samples will be taken weekly within two weeks, similar to the Raman measurements.

Conditions

• Dermatologic Disorders
• Disorder of Cholesterol Metabolism

Interventions

Type	Name	Description
PROCEDURE	Venous blood collection	weekly within two weeks
PROCEDURE	Raman spectroscopy	weekly within two weeks, on the volar forearm, using a RiverDiagnostics gen2-SCA Skin Composition Analyzer

Timeline

• Start date: 2016-07-01
• Primary completion: 2016-07-01
• Completion: 2016-07-01
• First posted: 2016-08-03
• Last updated: 2016-08-03