NCT02854410

Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients

Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients Pre and Post Concurrent Chemo-radiation Therapy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Capital Medical University · Academic / Other
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate whether dietary nitrate supplementation could improve the salivary flow for nasopharyngeal carcinoma patients receiving concurrent chemo-radiation therapy.

Detailed description

Thirty patients diagnosed as nasopharyngeal carcinoma will be recruited. Nitrate supplement(Sodium nitrate: 0.5 mmol/kgbodyweight,bid) or placebo(sodium chloride: 0.5 mmol/kgbodyweight,bid) will be provided to the patients from 7 days before radiotherapy to one month after the finish of radiotherapy . The salivary flow and plasma nitrate levels will be determined before the course of nitrate supplementation and radiotherapy,before the course of radiotherapy,post the course of radiotherapy immediately and one month after the finish of radiotherapy.

Conditions

• Nasopharyngeal Carcinoma

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Sodium nitrate	Dietary intake:Sodium nitrate 0.5mmol/kgbodyweight,bid
DIETARY_SUPPLEMENT	sodium chloride	Dietary intake:sodium chloride 0.5mmol/kgbodyweight,bid

Timeline

• Start date: 2016-08-01
• Primary completion: 2018-08-01
• Completion: 2018-12-01
• First posted: 2016-08-03
• Last updated: 2016-08-03

Locations

1 site across 1 country: China