NCT02854397

Determination of Specific Biomarkers of Acute Attack of Angioedema Within Pediatric Population

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 31 (actual)
• Sponsor: University Hospital, Grenoble · Academic / Other
• Sex: All
• Age: 1 Year – 18 Years
• Healthy volunteers: Accepted

Summary

In emergency room, this is crucial to diagnose an acute attack of hereditary angioedema (HAE) to quickly provide the efficient treatment. Currently, there is no specific biomarker for acute attack of bradykinin-mediated angioedema to help clinicians for patient care. However, previous works are carried out for that purpose. All the potential candidate biomarkers must be validated in prospective studies to estimate their specificity and sensitivity values, and to understand their potential utility in patient care. The main goal of this clinical trial is to estimate the diagnostic value of VE-cadherin in pediatric population, for the differential diagnosis between HAE crisis and angioedema resulting of mast cell activation crisis (the main differential diagnosis of HAE).

Conditions

• Hereditary Angioedema
• Healthy Volunteers

Interventions

Type	Name	Description
OTHER	blood sample

Timeline

• Start date: 2016-02-15
• Primary completion: 2020-06-01
• Completion: 2020-06-01
• First posted: 2016-08-03
• Last updated: 2020-11-18

Locations

14 sites across 1 country: France