NCT02853734

Inflammatory Status of Visceral Adipose Tissue in Obese Patients Related to Periodontitis Severity

Comparative Evaluation of the Inflammatory Status of Visceral Adipose Tissue From Obese Patients According to the Presence and Severity of Periodontitis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 122 (estimated)
• Sponsor: Centre Hospitalier Universitaire de la Réunion · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The research aims to compare the inflammatory status of visceral adipose tissue from obese patients depending on the presence and severity of periodontitis, in order to establish a potential causal link between the severity of the bacterial contamination and insulin resistance.

Detailed description

Recruitment of patients will be achieved in the department of digestive surgery. It will involve 122 patients with severe obesity undergoing bariatric surgery scheduled within the digestive surgery department. Patients recruited will be examined for evaluating the presence and severity of periodontitis, and separated into either group 1: for patients with moderate or severe periodontitis, and or group 2: for patients without or with mild periodontitis. The day before the surgery, blood sample will be collected for the analysis of circulating metabolic and inflammatory markers. Collection of stimulated saliva, periodontal sample and faeces samples (50 g) will also be carried out for bacteria determination. During the surgical procedure, a sample of visceral adipose tissue (50 g) will be collected and used for periodontal bacteria detection and inflammatory markers analyses.

Conditions

• Parodontitis
• Obesity
• Metabolism Disorders

Interventions

Type	Name	Description
OTHER	SEVERE PERIODONTITIS	Patients exhibiting moderate to severe periodontitis
OTHER	NO PERIODONTITIS	Patients without existing periodontitis or exhibiting mild periodontitis

Timeline

• Start date: 2019-03-12
• Primary completion: 2020-07-01
• Completion: 2021-07-01
• First posted: 2016-08-03
• Last updated: 2020-03-04

Locations

1 site across 1 country: Reunion