NCT02853721

Early Prediction of Hypocalcaemia Following Thyroid Surgery

Early Prediction of Hypocalcaemia Following Thyroid Surgery: A Prospective Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: University of Cagliari · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

150 patients divided into two groups.The experimental group was submitted at the assay of iPTH six hours after surgery whilst the control group was submitted to a daily assay of serum calcium and phosphorus.

Detailed description

Purpose: The aim of this randomized controlled trial was to validate the results of a previous prospective cohort study conducted in the same surgical unit regarding the use of concomitant intact parathyroid hormone (iPTH) and serum calcium measurement in predicting hypocalcemia after total thyroidectomy. Methods: From January 2014 to January 2015, 150 patients underwent total thyroidectomy in our department and were divided into two groups. The experimental group was submitted at the assay of iPTH six hours after surgery whilst the control group was submitted to a daily assay of serum calcium and phosphorus. Sensitivity and specificity of different serum measurements have been calculated using the Receiver-operator characteristics (ROC) curve.

Conditions

• Hypocalcemia

Interventions

Type	Name	Description
OTHER	iPTH	iPTH assay six hours after surgery
OTHER	no dosage of iPTH	Ca and P on postoperative day 1 and 2

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-01-01
• Completion: 2015-04-01
• First posted: 2016-08-03
• Last updated: 2016-08-03