NCT02850445

Trial and Follow-up of the Efficacy of Two-stage Integrated Treatment for Chinese Schizophrenia Inpatients

Effects of Integrated Treatment for Chinese Patients With Schizophrenia: 1-year Follow-up

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 170 (estimated)
• Sponsor: Guangzhou Psychiatric Hospital · Other Government
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Regular psychosocial intervention combined with antipsychotic drugs, compared with usual medication alone treatments, can reduce psychiatric symptoms and improve quality of life in patients with schizophrenia. However, it's expensive, time-consuming, and sometimes inconvenient for patients and their family members in developing areas where the number of well-trained therapist remains limited in local psychiatric settings. The investigators aimed to establish an efficient model of integrated treatment (IT) for patients with schizophrenia. The procedure contains two stages: a centralized treatment during hospitalization and the following consolidation treatments with long intervals.

Conditions

• Schizophrenia

Interventions

Type	Name	Description
DRUG	Olanzapine	All patients with schizophrenia were under medication treatment at the baseline. Individualized plan of antipsychotic medication for the patients were determined by psychiatrist who were blind to the group allocation. Medications could be changed at any time during the course of the study if the change was clinically warranted, the drug can also be any other antipsychotic medication.
OTHER	Cognitive behavior therapy	Patients with schizophrenia allocated to the Integrated Treatment(IT) group received Cognitive behavioral therapy.
OTHER	Rehabilitation treatment	Rehabilitation treatment include three modules: medication management, symptom management, and social kill training. Patients with schizophrenia allocated to the Integrated Treatment(IT) group received Rehabilitation treatment therapy.
OTHER	Case management	Patients with schizophrenia allocated to the Integrated Treatment(IT) group received Case management.

Timeline

• Start date: 2012-01-01
• Primary completion: 2016-12-01
• First posted: 2016-08-01
• Last updated: 2016-08-01

Locations

1 site across 1 country: China