NCT02850367

Effect of NO Precursors on Physiological Responses to Exercise

The Effect of NO Precursors on Physiological Responses to Exercise

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: University Hospital, Grenoble · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.

Conditions

• Physiology

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Nitrate	Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.
DIETARY_SUPPLEMENT	Nitrate and L-Arginine	Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.
DIETARY_SUPPLEMENT	Nitrate and L-Citrulline	Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with NO precursors.
DIETARY_SUPPLEMENT	Placebo	Subjects will be supplemented orally either acutely or chronically (4-8 weeks) with a placebo.
BIOLOGICAL	Evaluation of post-ischemic vascular reactivity	After the intake of the supplement. Concentration of hemoglobin (g/mL) in the quadriceps with the device : NIRS system Oxymon, ARTINIS.
BIOLOGICAL	Neuromuscular evaluations	After the intake of the supplement. Measure the stretching force in the ankle (N)

Timeline

• Start date: 2016-05-09
• Primary completion: 2021-09-01
• Completion: 2021-09-01
• First posted: 2016-08-01
• Last updated: 2025-12-29

Locations

1 site across 1 country: France