NCT02849015

Combination of Cryosurgery and NK Immunotherapy for Tumors in Transplanted Liver

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Fuda Cancer Hospital, Guangzhou · Academic / Other
• Sex: All
• Age: 30 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is the safety and efficacy of cryosurgery plus natural killer(NK) immunotherapy to tumors in transplanted liver.

Detailed description

By enrolling patients with tumors in transplanted liver adapted to enrolled criteria, this study will document for the first time the safety and the short and long term efficacy of the combined therapy using cryosurgery and NK cells. The safety will be evaluated by statistics of adverse reactions. The efficacy will be evaluated according to local relief degree, progress free survival (PFS) and overall survival (OS).

Conditions

• Liver Tumor
• Evidence of Liver Transplantation

Interventions

Type	Name	Description
DEVICE	Cryosurgery	Argon-helium cryosurgical system (percutaneous ablation under CT or ultrasound guidance)
BIOLOGICAL	NK immunotherapy	Natural killer cell(each treatment: about 10 billion cells transfusion in 3 times, i.v.)

Timeline

• Start date: 2016-07-01
• Primary completion: 2017-07-01
• Completion: 2018-07-01
• First posted: 2016-07-29
• Last updated: 2019-09-12

Locations

1 site across 1 country: China