NCT02847143

Ocytocine and Cerebral Activation in Relation With Attachement

A Cross Over Randomized Controlled Trial of the Effect of Nasal Ocytocine on Cerebral Activations in Relation With Attachement in the General Population

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Centre Hospitalier Universitaire de Besancon · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The study aims to characterize the cerebral activation modifications related to nasal oxytocin administration during vizualisation of distress images in population of healthy people with different attachement styles.

Detailed description

Healthy adult male will be recruited. Their attachement style will be assessed through the Attachement scale interview (ASI). They will have 2 fMRI sessions, during which emotional images will be presented. One session will be preceded by a nasal administration of oxytocin and the other session will be preceded by a placebo nasal administration. The order of both administrations will be randomized.

Conditions

• Attachement Style

Interventions

Type	Name	Description
DRUG	nasal oxytocin or placebo	nasal administration of oxytocin or palcebo 45 min befor fMRI session
DEVICE	fMRI	FMRI during emotional image visualization
BEHAVIORAL	Attachement scale interview (ASI)	this scale is used to determine the attachement style of each participant
BEHAVIORAL	psychometric scales	self adminstrated questionnaires which asses the level of anxiety (Spielberger State-trait anxiety interview-STAI), depression (Beck depression inventory-BDI) and alexithymia (Toronta Alexuthymia scale-TAS 20)

Timeline

• Start date: 2015-04-09
• Primary completion: 2018-04-27
• Completion: 2018-04-27
• First posted: 2016-07-28
• Last updated: 2024-10-02

Locations

1 site across 1 country: France