NCT02843139

Circulating microRNAs for Discriminating Obese Preschoolers at Risk of Diabetes

Circulating microRNAs as Novel Prognostic Biomarkers in Obese Preschoolers at Risk for Type 2 Diabetes in Adulthood

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 535 (actual)
• Sponsor: Nanjing Medical University · Academic / Other
• Sex: All
• Age: 48 Months – 72 Months
• Healthy volunteers: Accepted

Summary

Childhood obesity certainly increases susceptibility to type 2 diabetes (T2D) in adulthood. Recently, microRNAs (miRNAs) are closely related to various diseases and have been suggested as valuable biomarkers. Here, we sought to identify potential miRNAs to discriminate obese children at risk for diabetes in future.

Detailed description

This study was designed to screen the circulating miRNAs in association with progression from children obesity to type 2 diabetes (T2D) in adulthood. Serum samples were evaluated in a 3 step procedure: 1) discovery study, in which samples from obese children and healthy controls were pooled for miRNA sequecing experiment; 2) cross-sectional validation study, in which miRNAs of interest were validated in all individuals (obese children, overweight children and normal controls); 3) longitudinal validation study, in which the candidate miRNAs were estimated in newly diagnosed diabetes patients and normal glucose tolerance controls (NGT). The final determined miRNAs were further confirmed though primary function studies.

Conditions

• Discriminate Obese Children at Risk for Diabetes.

Timeline

• Start date: 2014-04-01
• Primary completion: 2015-10-01
• Completion: 2016-03-01
• First posted: 2016-07-25
• Last updated: 2016-07-25

Locations

1 site across 1 country: China