Trials / Completed
CompletedNCT02839044
A Randomized, Placebo-controlled, Double Blind Trial to Investigate Whether Vitamin K2 Can Influence Arterial Calcification in Patients With Type 2 Diabetes
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 68 (actual)
- Sponsor
- UMC Utrecht · Academic / Other
- Sex
- All
- Age
- 40 Years
- Healthy volunteers
- Not accepted
Summary
Arterial calcification is an independent predictor of coronary events associated with a 3-4 fold increased risk of cardiovascular events. Currently, no effective intervention exists to reduce arterial calcification. However, recent studies showed that vitamin K may reduce ongoing calcium deposition in the arteries, and thereby inhibit arterial calcification. The primary objective is to determine if MK-7 supplementation leads to stabilization or attenuation of ongoing calcium deposition in the femoral artery as quantified by 18F-NaF PET/CT imaging in patients with type 2 diabetes and arterial disease.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | Menaquinone-7 | |
| DIETARY_SUPPLEMENT | Placebo |
Timeline
- Start date
- 2016-06-01
- Primary completion
- 2018-09-01
- Completion
- 2018-12-01
- First posted
- 2016-07-20
- Last updated
- 2019-10-02
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT02839044. Inclusion in this directory is not an endorsement.