NCT02837640

Studying a Potential Protective Effect of L-Dopa on Retinitis Pigmentosa

The Effect of L-Dopa on the Progression of Retinitis Pigmentosa

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Beirut Eye Specialist Hospital · Academic / Other
• Sex: All
• Age: 10 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the effect of L-Dopa on the progression of retinitis pigmentosa.

Detailed description

Retinitis pigmentosa is a group of progressive hereditary diseases that diffusely affects the functioning of photoreceptors and the pigment epithelium. It may be speculated that a protective effect on the pigment epithelium, as it is supposed for L-Dopa, can slow the progression of the disease or even lead to an, at least transient, improvement of visual functions. To evaluate the effect of L-Dopa on retinitis pigmentosa progression, visual acuity, electroretinogram and visual field will be preformed regularly.

Conditions

• Retinitis Pigmentosa

Interventions

Type	Name	Description
DRUG	levodopa-carbidopa	sinemet 200/50 1/2 tablet b.i.d. for 2 days and then t.i.d for 6 months

Timeline

• Start date: 2016-06-01
• Primary completion: 2017-06-01
• Completion: 2021-06-01
• First posted: 2016-07-19
• Last updated: 2016-07-19

Locations

1 site across 1 country: Lebanon