NCT02829216

Graft-versus-host Disease Associated Myelosuppression

Functional Profiling of the Hematopoietic Stem Cell Niche in Graft Versus Host Disease Mediated Bone Marrow Insufficiency

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Technische Universität Dresden · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The objective is to measure the frequency, functionality and phenotype of bone marrow-derived mesenchymal stromal cells in patients after allogeneic hematopoietic stem cell transplantation. Furthermore, the immune cell infiltrate of the bone marrow will be monitored at the same time. These results will be correlated with the extent of cytopenia and clinical graft-versus-host disease grading.

Conditions

• Abnormal Hematopoiesis
• Allogenic Disease
• Graft vs Host Disease

Timeline

• Start date: 2016-04-01
• Primary completion: 2017-04-01
• First posted: 2016-07-12
• Last updated: 2016-07-12

Locations

1 site across 1 country: Germany