Trials / Completed
CompletedNCT02828670
Role of T Follicular Helper Cells in Autoimmune Hemolytic Anemia (TFH in AIHA)
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 25 (actual)
- Sponsor
- Centre Hospitalier Universitaire Dijon · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
T follicular helper (TFH) cells represent a T cell subset dedicated to the activation of B cells. They have been involved in the pathogenesis of autoimmune diseases in humans such as lupus and Sjögren disease. We recently showed that TFH are implicated in the activation of autoreactive B lymphocytes during ITP. Autoimmune hemolytic anemia (AIHA) is an autoimmune disease due to antibodies targeting red blood cells. To date, the role of TFH in the pathogenesis of AIHA is not known. We hypothesize that AIHA is associated with an increase in the number and/or function of TFH, that could participate in the activation of autoreactive B lymphocytes.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | blood sample | |
| PROCEDURE | spleen sample |
Timeline
- Start date
- 2016-06-07
- Primary completion
- 2022-02-15
- Completion
- 2022-02-15
- First posted
- 2016-07-11
- Last updated
- 2024-07-15
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT02828670. Inclusion in this directory is not an endorsement.