NCT02826629

"Manual Dexterity and Oculomotor Control in Schizophrenia"

"MADOCS: Manual Dexterity and Oculomotor Control as Vulnerability Markers in Schizophrenia"

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 105 (estimated)
• Sponsor: Centre Hospitalier St Anne · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The investigators recently showed that visuomotor integration was significantly altered in schizophrenic patients during: (i) a grip force task (Teremetz et al., 2014), and (ii) a saccadic paradigm (oculomotor task)(Amado et al., 2008). Given this findings, the investigators propose a combined study of oculomotor and grip force control to better characterize the sensorimotor integration deficit. This approach may allow for identification of behavioural biomarkers of vulnerability to develop schizophrenia.

Detailed description

1 - Scientific background and rational Use of sensory cues is essential for execution and correction of voluntary movements. The motor areas and their regulation is of special interest in patients with schizophrenia as there is clear evidence of motor abnormalities independent of the effects of antipsychotic medication, even before the onset of the disorder. Sensorimotor abnormalities have been proposed as a valid endophenotype in schizophrenia. Our global objective is to study and provide vulnerability markers for schizophrenia. 1. Control of manual dexterity will be assessed by a force sensor (Power Grip Manipulandum, PGM) 2. Oculomotor movements during behavioral task will be recorded using a video-oculography device 3. The involvement of cortical inhibition in this volitional inhibition task will be studied by neuronavigation guided TMS coupled to EMG recording 2 - Description of the project methodology There is strong evidence for schizophrenia being a neuro-developmental disorder (Rapoport et al., 2005). It has been shown, for many years, that patients with schizophrenia exhibit abnormal patterns of sensorimotor integration (Manschreck et al., 1982), which is the capacity to integrate different sensory stimuli into appropriate motor actions. It is clinically relevant, in terms of early diagnosis and prevention, whether deficient sensorimotor integration is present in the prodromal phase of schizophrenia, and whether this constitutes a vulnerability marker for the disease. Our global objective is to study the interactions and related substratum of oculomotor movements during force control task. The secondary objectives: (i) To show that increased motor noise is indeed present in schizophrenia. (ii) To show by TMS that cortical excitability in the primary motor cortex (M1) is task-modulated and decreased in schizophrenia. (iii) Assess the role of deficient cortical inhibition in these behavioral deficits To this end, three different groups of subjects will be studied: schizophrenic patients, non-affected siblings, ultra high risk patients, non-treated schizophrenic patients and healthy control subjects.

Conditions

• Schizophrenia

Interventions

Type	Name	Description
DEVICE	Manual dexterity	Control of manual dexterity will be assessed by a force sensor (Power Grip Manipulandum, PGM)
DEVICE	Oculomotor movements	Oculomotor movements during behavioral task will be recorded using a video-oculography device
DEVICE	TMS coupled to EMG recording	The involvement of cortical inhibition in this volitional inhibition task will be studied by neuronavigation guided TMS coupled to EMG recording
OTHER	Psychopathological evaluations
OTHER	Neuropsychological evaluations

Timeline

• Start date: 2016-07-26
• Primary completion: 2018-09-01
• Completion: 2019-01-01
• First posted: 2016-07-11
• Last updated: 2017-10-19

Locations

2 sites across 1 country: France