NCT02826057

The Complement Lectin Pathway After Cardiac Arrest

The Complement Lectin Pathway in Patients Resuscitated After Cardiac Arrest

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 82 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study includes comatose survivors of out-of-hospital cardiac arrest treated with 24 hours or 48 hours of targeted temperature management. The overall aim is to evaluate the importance of plasma complement protein concentrations in patients resuscitated after out-of-hospital cardiac arrest and treated with 24 hours or 48 hours of targeted temperature management. The specific aim is to evaluate: * the concentration of plasma lectin pathway proteins the first, second and third day after cardiac arrest * the relation between concentration of plasma lectin pathway proteins and mortality * if prolonged targeted temperature management influences the concentration of plasma lectin pathway proteins This study is a sub-study to the trial entitled: "Time-differentiated targeted temperature management (TTH48) (ClinicalTrials.gov Identifier: NCT01689077)" The following Complement Lectin Pathway proteins will be measured: Mannan-Binding-Lectin, M-ficolin, H-ficolin, CL-L1, MASP-1, MASP-2, MASP-3, MAp19 and MAp44.

Conditions

• Out-of-Hospital Cardiac Arrest
• Post Cardiac Arrest Syndrome

Interventions

Type	Name	Description
OTHER	Targeted temperature management (33 degree Celsius)

Timeline

• Start date: 2016-02-01
• Primary completion: 2016-07-01
• Completion: 2017-07-01
• First posted: 2016-07-07
• Last updated: 2016-07-07

Locations

3 sites across 1 country: Denmark