NCT02825459

Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 147 (actual)
• Sponsor: University of Vermont · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to see whether adults who use e-cigarettes every day experience symptoms of nicotine withdrawal when they stop using e-cigarettes for 6 days.

Detailed description

Study Design: The investigators will recruit 120 individuals who are long-term daily and exclusive users of nicotine-containing e-cigarettes. Participants will be asked to use their own e-cigarette as usual during the first week of the study and to then stop their use of e-cigarettes for 6 days. The total study duration will be 14 days. Participants will be instructed to continue abstinence from other tobacco and nicotine products during the entire study. The investigators will use an escalating payment system with bonuses based on breath and urine samples to encourage compliance. Every day during the study, participants will report e-cigarette and tobacco cigarette use and monitor symptoms of nicotine withdrawal via a phone call to an Interactive Voice Response system. Participants will attend 3 study visits each week to provide urine and breath samples to verify compliance, and to complete brief surveys.

Conditions

• Substance Withdrawal Syndrome

Interventions

Type	Name	Description
BEHAVIORAL	Abstinence from e-cigarettes	Abrupt cessation for 6 days

Timeline

• Start date: 2016-07-01
• Primary completion: 2018-10-31
• Completion: 2018-10-31
• First posted: 2016-07-07
• Last updated: 2018-11-20

Locations

2 sites across 1 country: United States