Trials / Unknown
UnknownNCT02824835
Strigolactones and Dysplastic Colonic Lesions or Cancer
The Effect of the Plant Hormones Strigolactones on Cultures of Dysplastic Colonic Lesions and Cancer
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 150 (estimated)
- Sponsor
- Meir Medical Center · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to determine the effects of the plant hormones strigolactones, on cell cultures of colonic polyps and colorectal cancer.
Detailed description
Strigolactones have been shown to anti-proliferative and pro-apoptotic effects in cell cultures of breast and prostate origin, partially by down-regulation of cyclin B1 and induction of cell cycle arrest. In this study the investigators intend to take biopsies from benign colonic polyps and cancer tissue, culture intestinal explants and generate immortalized primary cells as a platform to assess the effect of this plant hormone on cell viability, cell mobility, apoptosis and cytoskeleton modifications.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | biopsy during colonoscopy | sampling the lesion with forcept biopter |
Timeline
- Start date
- 2016-07-01
- Primary completion
- 2017-12-01
- Completion
- 2017-12-01
- First posted
- 2016-07-07
- Last updated
- 2016-07-07
Source: ClinicalTrials.gov record NCT02824835. Inclusion in this directory is not an endorsement.