NCT02823665

The Effects of Bariatric Surgeries on Glucose Metabolism

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: The University of Texas Health Science Center at San Antonio · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.

Detailed description

The purpose of this study is to determine the weight-independent effects of gastric bypass surgery and sleeve gastrectomy surgery on islet cell response after meal ingestion as mediated by hormonal and neural components of the gut. It will also address the differences between the two procedures. Such information will be critical for the development of novel approaches for treatment of diabetes as well as improvement of glycemic effects of gastric bypass and sleeve gastrectomy in patients with partial diabetes remission or relapse after complete remission.

Conditions

• Post Bariatric Surgery
• Gastric Bypass
• Sleeve Gastrectomy
• Hypoglycemia After Gastric Bypass

Interventions

Type	Name	Description
DRUG	Exendin-(9-39)	A physiological study to evaluate the role of GLP-1 on glucose metabolism and insulin secretin after glucose and protein ingestion.
DRUG	Atropine	A physiological study to evaluate the effect of neural activation on insulin secretion and glucose metabolism.

Timeline

• Start date: 2015-07-01
• Primary completion: 2026-08-01
• Completion: 2027-08-01
• First posted: 2016-07-06
• Last updated: 2025-09-09

Locations

2 sites across 1 country: United States