NCT02822144

General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 351 (actual)
• Sponsor: Rennes University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In France, the annual incidence rate of acute ischaemic stroke is around 150 000 patients, 65 % of whom keep long-term disability. Several multicentric randomized controlled trials have shown the benefit of a mechanical thrombectomy in the acute phase of ischaemic stroke on functional disability, compared to a medical treatment alone (thrombolysis). The timeliness of revascularisation is an essential factor of good prognosis. This intra-arterial treatment, associated with thrombolysis if applicable, is the reference treatment of large-vessel occlusion. The stillness of the patient is required to control the safety of the recanalization. Currently, either a general anesthesia or a sedation can be performed. Several studies have shown a trend to superiority of the sedation but none was conducted with a high level of proof methodology. The aim of our multicentric randomized controlled trial is to compare sedation and general anesthesia during intra-arterial thrombectomy for an acute ischaemic stroke in the anterior cerebral circulation. The main outcome will be the efficacy on the functional neurological prognosis at 3 months.

Conditions

• Stroke

Interventions

Type	Name	Description
DRUG	Etomidate
DRUG	Succinylcholine
DRUG	Propofol
DRUG	Remifentanil
DRUG	Lidocaine

Timeline

• Start date: 2016-09-29
• Primary completion: 2020-08-01
• Completion: 2020-08-01
• First posted: 2016-07-04
• Last updated: 2023-05-23

Locations

4 sites across 1 country: France