NCT02821273

Surfactant Administration in Preterm Infants

Modified INSURE vs INSURE in Preterm Infants With Respiratory Distress Syndrome: A Randomized Controlled Trials

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Academic / Other
• Sex: All
• Age: 6 Hours
• Healthy volunteers: Not accepted

Summary

In preterm infants with respiratory distress syndrome, mechanical ventilation is related to increased risk of death and complications. Surfactant is an important methods to reduce mortality and intubation rates. INSURE technique is a standard method to administrate surfactant. However, several preterm infants need two or more surfactant, and therefore one more intubation is needed. How to reduce the times of intubation is an challenges for neonatologists.

Detailed description

INSURE technique meas surfactant administration through intubation-surfactant-extubation. And noninvasive ventilation is immediately used after surfactant. The differences of modified INSURE compared with INSURE is intubation-surfactant-X-ray relieved-extubation. Extubation and noninvasive ventilation is used after the X-ray relieving.

Conditions

• Modified INSURE Technique

Interventions

Type	Name	Description
OTHER	Modified INSURE technique	modified INSURE means intubation-surfactant-X-ray relieved-extubation. Extubation and noninvasive ventilation is used after the X-ray relieving.
OTHER	INSURE technique	INSURE means intubation-surfactant-extubation. Extubation and noninvasive ventilation is used after surfactant administration.

Timeline

• Start date: 2016-06-01
• Primary completion: 2023-12-01
• Completion: 2023-12-31
• First posted: 2016-07-01
• Last updated: 2022-10-14

Locations

1 site across 1 country: China