NCT02817815

Atrial Fibrillation and Characterization of Blood Platelet

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 86 (actual)
• Sponsor: University Hospital, Bordeaux · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Arterial thromboembolism constitutes a major risk of atrial fibrillation (AF) requiring antithrombotic therapy. Platelets and microparticles (MPs) are important for hemostasis and thrombosis, their role during AF is not well known. The principal objective of this study is to compare morphologic, functional and proteomics characteristics of blood platelet between AF patients and healthy volunteers.

Detailed description

AF is associated with decreased quality of life and an increased risk of thromboembolic events. AF is the leading cause of embolic stroke. Identification of factors that may influence blood coagulability in these patients could better identify therapeutic targets to optimize anticoagulation. Platelets play a major role in the coagulation process, their study may provide valuable information. Moreover microparticles from platelet activation are known to have pathophysiological effects including effects on thrombosis and inhibition of fibrinolysis. It has also been shown that the microparticles have a role in endothelial dysfunction and generation of inflammatory condition which are associated with atrial fibrillation. Investigators propose in this project, a comparative study between AF patients and healthy volunteers. Complete characterization of platelet (morphology, platelet function, platelet proteome) and microparticles levels will be perform. Different site blood sampling (systemic or cardiac) will be done in patients during their ablation procedure. Patients will be followed during their hospitalisation.

Conditions

• Atrial Fibrillation

Interventions

Type	Name	Description
DEVICE	Electrocardiogram (ECG)
BIOLOGICAL	Blood sampling from the cephalic vein
BIOLOGICAL	Blood sampling from the femoral vein	Blood sampling will be done during radiofrequency ablation of AF procedure, after the introduction of catheter
BIOLOGICAL	First blood sampling from left atrium	Blood sampling will be done during radiofrequency ablation of AF procedure, after transeptal punction
PROCEDURE	Atrial stimulation	Patients will receive atrial stimulation with the catheter positioned in the coronary sinus to induce AF
BIOLOGICAL	Second blood sampling from left atrium	After 20min of continuous AF, a blood sampling from left atrium will be done

Timeline

• Start date: 2016-11-02
• Primary completion: 2018-10-26
• Completion: 2018-10-26
• First posted: 2016-06-29
• Last updated: 2022-02-28

Locations

1 site across 1 country: France