NCT02813538

Major Liver Resection: Early Clotting Disorders and Functional Impairment.

Hypercoagulability and Liver Function After Major Liver Resection

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Hospital General Universitario Gregorio Marañon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate early clotting disorders through thromboelastogram and anticoagulant proteins levels (maybe also endothelial markers) and liver function by indocyanine green clearance after major liver resection and search for a potential relationship between them.

Detailed description

We are prospectively recording data from patients undergoing major liver resection. We obtain a full procoagulant and anticoagulant profile preoperatively and, at first, second and sixth day after surgery. We also measure indocyanine green (ICG) clearance preoperatively and in the first two postoperative days. We are also recording clinical data, focusing on medical and surgical complications. We aim to establish the potential value of ICG clearance and or coagulation profile to predict clinical complications

Conditions

• Hepatic Insufficiency
• Blood Coagulation Disorders

Interventions

Type	Name	Description
DRUG	Indocyanine green clearance	To evaluate liver function by injection of indocyanine green by a peripheral vein and measure its clearance
OTHER	Thromboelastometry	To evaluate blood coagulation impairment by obtaining blood sample from a peripheral vein and measure anticoagulant proteins levels plus obtaining thromboelastometry

Timeline

• Start date: 2016-02-05
• Primary completion: 2018-10-01
• Completion: 2019-04-01
• First posted: 2016-06-27
• Last updated: 2020-05-21

Locations

1 site across 1 country: Spain