NCT02812979

Evaluation of the Effectiveness of the Nebulization Bronchodilators Under High Nasal Flow Humidified

Evaluation of the Effectiveness of the Nebulization Bronchodilators Under High Nasal Flow Humidified Compared to a Usual Method

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: University Hospital, Tours · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The principal objective is to show noninferiority of nebulized salbutamol through the high flow nasal system moistened AIRVO ™ 2 in terms of reversibility of airflow obstruction compared to nebulization by the usual method (spray mask).

Detailed description

Randomized, comparative, non inferiority study between two nebulization strategies bronchodilators, one according to the method tested namely the spray - in across the top humidified nasal flow system and the other according to a customary procedure, through a mask. A third arm will be evaluated (control arm) to overcome a possible own bronchodilator effect of high flow nasal humidified.

Conditions

• Chronic Obstructive Pulmonary Disease

Interventions

Type	Name	Description
DEVICE	Airvo2 with Aerogen Solo	Nebulization of salbutamol with Airvo 2 and Aerogen solo
DEVICE	Mask	Usual nebulization of salbutamol with mask
DEVICE	arm control Airvo2 without nebulization of salbutamol	Airvo2 with Aerogen Solo. No nebulization of salbutamol

Timeline

• Start date: 2016-06-01
• Primary completion: 2018-04-27
• Completion: 2018-04-27
• First posted: 2016-06-24
• Last updated: 2025-12-22

Locations

1 site across 1 country: France