NCT02810496

Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia

Prevalence of Mutations of Glucocorticoid Receptors in Bilateral Adrenal Hyperplasia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: CHU de Reims · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

As the investigators observed a case of glucocorticoid mutation revealed by incidentally discovered bilateral adrenal nodular hyperplasia, it was postulated that this molecular anormality could be more frequent than previously described. To validate this hypothesis, it was decided to study 150 multicenter consecutive patients, presenting with incidentally discovered bilateral adrenal masses without clinical signs of Cushing's disease. In all these patients GR gene will be studied, mutations will be detected and described, functional disturbance will be tested. Usual polymorphisms will be described. Correlation between clinical signs, hormonal and morphological abnormalities and presence or absence of GR mutations will be searched.

Conditions

• General Glucocorticoid Resistance

Interventions

Type	Name	Description
GENETIC	blood collection for mutation characterization

Timeline

• Start date: 2012-04-02
• Primary completion: 2016-10-02
• Completion: 2016-12-31
• First posted: 2016-06-23
• Last updated: 2026-01-21

Locations

1 site across 1 country: France