NCT02809820

Effects of Beta-blockade on Platelet Aggregation in Acute Coronary Syndrome

Effects of Selective and Nonselective Beta-blockade on Platelet Aggregation in Patients With Acute Coronary Syndrome

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Federico II University · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The Investigators will test the hypothesis that nonselective beta-blockers would have a more pronounced effect on platelet aggregation than selective beta-blockers in patients with acute coronary syndrome treated with dual anti platelet therapy.

Detailed description

In patients with acute coronary syndrome (ACS) beta-blockers are recommended for secondary prevention. It is known that catecholamine levels can potentiate platelet reactivity and beta-blocking agents may also affect platelet aggregation. This effect is mainly mediated by adrenergic receptors on platelets. This suggests that nonselective beta-blockers would have a more pronounced effect on platelet aggregation than selective beta-blockers. However, little is known about the effect of beta-blockers on platelet aggregation in patients with cardiovascular disease and, to date, nothing is known in the setting of ACS. The aim of the present study is to evaluate the effect of selective and nonselective beta-blockers on platelet aggregation in ACS patients treated with dual anti platelet therapy.

Conditions

• Acute Coronary Syndrome

Interventions

Type	Name	Description
DRUG	Carvedilol	Patients randomized to this group will receive carvedilol at the highest dose tolerated
DRUG	Metoprolol	Patients randomized to this group will receive metoprolol at the highest dose tolerated

Timeline

• Start date: 2016-05-01
• Primary completion: 2016-12-01
• Completion: 2016-12-01
• First posted: 2016-06-22
• Last updated: 2022-03-31

Locations

1 site across 1 country: Italy