NCT02809378

The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV

The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of Postoperative Nausea and Vomiting in the Women Patients Undergoing Thyroidectomy

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: Female
• Age: 20 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The incidence of postoperative nausea and vomiting (PONV) after thyroidectomy have been shown to be relatively high compared other surgeries, with a reported incidence 65-75 %. PONV may increase patient discomfort, delay patient discharge, and increase the cost of patient care, the risk of postoperative bleeding which may potentially cause airway obstruction. It is reported that the maintenance of anesthesia with propofol-remifentanil or sevoflurane-propofol-remifentanil decreased the incidence of PONV compared sevoflurane alone, but failed to demonstrate the decreased incidence of PONV in 6-24 hr postoperative period in patients undergoing thyroidectomy. Administration of Palonosetron, newly developed 5-HT3 antagonists with long half life (48 hrs) may decrease the incidence of PONV particularly during this period. The purpose of this study was to evaluate and compare the incidence of PONV after thyroidectomy with three different anesthetic methods, sevoflurane or sevoflurane-propofol-remifentanil or sevoflurane-propofol-remifentanil-palonosetron in woman patients.

Conditions

• PONV
• Palonosetron
• Anesthesia

Interventions

Type	Name	Description
DRUG	Palonosetron	newly developed 5-HT3 antagonists with long half life (48 hrs) intravenous administration prior to anesthesia induction
DRUG	sevoflurane	Inhalational anesthetics Halogenated.
DRUG	remifentanil	ultra-short acting opioid anesthetics
DRUG	pentothal sodium	intra-venous anesthetics for anesthesia induction
DRUG	propofol	intra-venous anesthetics for anesthesia induction and maintenance

Timeline

• Start date: 2016-06-01
• Primary completion: 2017-04-20
• Completion: 2017-04-20
• First posted: 2016-06-22
• Last updated: 2017-07-21

Locations

1 site across 1 country: South Korea