NCT02808611

Influence of Propranolol on Conditioned Pain Modulation

Konditionerende Smertestimuli - Sammenligning af Forskellige Test og Konditioneringsmodaliteter

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Kristian Kjær Petersen · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

An extensive amount of studies indicate that conditioned pain modulation (CPM) test paradigms can be of use to evaluate the efficacy of the endogenous pain inhibition pathway in healthy controls and pain patients. A number of studies indicate that the autonomic nervous system (ANS) responds to painful stimulation by parasympathetic activity withdrawal and up-regulation of sympathetic activity (flight-or-fight mode), but it remains unknown whether these responses predict individual pain susceptibility or CPM efficacy and whether different pain modalities evoke different physiological stress responses, i.e. do individuals with low pain tolerance exhibit more vigorous ANS responses when subjected to controlled acute pain stimuli, and do high ANS responsiveness to pain coincide with altered psychophysical pain levels/CPM efficacy. This study aims to investigate the effect of ANS responsiveness on CPM paradigms and to investigate if an exogenous, pharmaceutically induced decrease in the sympathetic drive of the ANS will yield decreased CPM efficacy.

Conditions

• Healthy Subjects

Interventions

Type	Name	Description
DRUG	propranolol	Reduction of the ANS response
DRUG	Placebo

Timeline

• Start date: 2016-07-01
• Primary completion: 2017-01-01
• Completion: 2017-01-01
• First posted: 2016-06-22
• Last updated: 2017-06-28

Locations

1 site across 1 country: Denmark