NCT02805478

Fat-Associated Cardiovascular Organ Dysfunction

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 618 (actual)
• Sponsor: Haukeland University Hospital · Academic / Other
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This is an observational study of cardiovascular risk factors and arterial or cardiac function in subjects with overweight or obesity. Subjects must be between 30 and 65 years of age, have a body mass index \>27.0 kg/m2 and free from known heart disease and digestive or psychiatric disorders. Study aims include identifying sex-differences in traditional cardiovascular risk factors and structural and functional abnormalities in arteries and the heart in subjects with overweight or obesity, and how this is influenced by physical fitness.

Detailed description

FATCOR is an observational study of women and men with overweight or obesity. In particular prevalences of conventional cardiovascular risk factors and subclinical arterial or cardiac dysfunction are explored. The study aims at identifying sex differences in presence and clustering of cardiovascular risk factors and presence of subclinical cardiovascular organ damage. The influence of physical fitness on these factors will also be assessed. All participants undergo extensive cardiovascular risk factor assessment including oral glucose tolerance test and ambulatory blood pressure recording. Subclinical cardiovascular dysfunction is assessed by carotid and femoral vascular ultrasound, echocardiography and carotid-femoral pulse wave velocity using applanation tonometry. Physical fitness is assessed from peak oxygen uptake during maximal exercise testing on a treadmill.

Conditions

• Overweight
• Obesity

Interventions

Type	Name	Description
OTHER	There is no intervention	This is a prospective observational cohort study without any intervention

Timeline

• Start date: 2009-09-05
• Primary completion: 2017-04-30
• Completion: 2017-04-30
• First posted: 2016-06-20
• Last updated: 2020-09-04

Locations

1 site across 1 country: Norway