NCT02804217

Acquired Resistant Mechanism of the First-generation EGFR TKIs

Identification of Genomic Mutation Profile Using Next Generation Sequencing for Non-small-cell Lung Cancer Patients With Activating EGFR Mutations Harboring Acquired Resistance to the First-generation EGFR TKIs.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Zhejiang Cancer Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Patients with advanced non-small-cell lung cancer (NSCLC) harboring sensitive epithelial growth factor receptor (EGFR) mutations invariably develop acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). Identification of actionable genetic mutations can be helpful for guiding the subsequent treatment. This study aimed to analyze the genetic profile of NSCLC harboring acquired resistance to the first-generation EGFR TKIs using next generation sequencing (NGS).

Conditions

• Non-small Cell Lung Cancer
• Aquired Resistance
• EGFR TKIs

Interventions

Type	Name	Description
OTHER	Genetic: mutation profile

Timeline

• Start date: 2016-06-01
• Primary completion: 2017-06-01
• First posted: 2016-06-17
• Last updated: 2016-06-21

Locations

1 site across 1 country: China